Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy: an observational study.

Allergen-specific immunotherapy (AIT) induces immune tolerance, showing the highest success rate (>95%) for insect venom while a much lower chance for pollen allergy. However, the molecular switches leading to successful durable tolerance restoration remain elusive. The primary outcome of this observational study is the comprehensive immunological cellular characterization during the AIT initiation phase, whereas the secondary outcomes are the serological and Th2-cell-type-specific transcriptomic analyses.

Recombinant antigen 5 from Polybia paulista wasp venom (Hymenoptera, Vespidae): Antigen-specific antibody production and functional profile of CD4 T cells in the immune response.

Polybia paulista is a neotropical social wasp related to severe accidents and allergic reactions cases, including anaphylaxis, in southeastern Brazil. Antigen 5 (Poly p 5) is a major allergenic protein from its venom with potential use for component-resolved diagnostic. Therefore, the previous characterization of the immune response profile triggered by Poly p 5 should be evaluated.

Psychosocial adaptation under adverse experiences: A study on the role of empathy with adolescents from vulnerable contexts in Brazil.

Background: Adverse Childhood Experiences (ACEs) are potentially traumatic events that affect children and adolescents, increasing the risk for negative outcomes in several developmental domains. The literature suggests that ACEs affect boys and girls differently, and that protective factors such as social and emotional skills may favor resilience processes and promote Psychosocial Adjustment.

Objective: The present study aimed to verify gender differences in relation to ACEs and Empathy, and to identify whether the effect of ACEs on Psychosocial Adjustment is moderated by Empathy.

Biological and Inflammatory Effects of Antigen 5 from (Hymenoptera, Vespidae) Venom in Mouse Intraperitoneal Macrophages.

The social wasp (Hymenoptera, Vespidae) is highly aggressive, being responsible for many medical occurrences. One of the most allergenic components of this venom is Antigen 5 (Poly p 5). The possible modulation of the in vitro immune response induced by antigen 5 from venom, expressed recombinantly (rPoly p 5), on BALB/c mice peritoneal macrophages, activated or not with LPS, was assessed.

Criminal Behavior and Psychosocial Risk Factors in Brazilian Adolescent Offenders: An Exploratory Latent Class Analysis.

Considering that adolescent offenders are quite a heterogeneous group in terms of behavioral and psychosocial variables, it is considered that a typological approach can assist in the systematization of these differences, aiming at a better understanding of the phenomenon and at clearer guidance in terms of interventions. Therefore, this study aimed to identify the behavioral and psychosocial profiles of male adolescent offenders, based on empirical data collected in a Brazilian sociocultural context. The profiles were made with a sample of 400 adolescent offenders to perform an exploratory latent classes analysis.