Activity-stress ulcers in rats: the role of preentrainment to meal time.

Rats housed in activity wheels (A-W) or hanging cages (H-C) received food restriction to 4 h/day for 15 days. Food was given at fixed times to entrain the feeding entrainable oscillator or at irregular times to prevent entrainment. One half of the rats received food in the light phase, the other half in the dark phase of the light-dark cycle.

Stress ulcers in rats: the role of food intake, body weight, and time of day.

Rats were housed in activity wheels (n = 32) or in hanging cages (n = 32) for 2 weeks. Food intake of rats in hanging cages was curtailed to match body weight to that of the activity group. All rats then received 6 g of food at one of four different times of day (n = 8, each mealtime) for 4 consecutive days and were sacrificed 24 h after the last meal.

Diet-induced obesity attenuates anticipation of food access in rats.

Rats were housed in hanging cages and given ad lib access to food (control), approximately 20 g food/day (lean), or a palatable high-fat diet (fat). After body weights diverged, rats were transferred to activity wheels. When food access was reduced to 2 h/day, all control and lean rats displayed anticipatory activity (AA), while only two of eight fat rats anticipated the meals.

New methods to detect the effect of alteration in gastric pH and intestinal transit by metoclopramide and propantheline using a continuous gastric pH probe and hydrogen breath analysis.

Unlabelled: The effects of oral doses of metoclopramide (M, 10 mg) and propantheline (P, 30 mg) on alteration in gastric pH and emptying were determined using a continuous pH probe (Digitrapper, Synectics) and hydrogen breath analysis (HBA, QuinTron) in eight male subjects. The four phases consisted of HBA, HBA and pH probe, and HBA and pH probe and either P or M. Baseline pH measurements were recorded for 60 min prior to dosing with 10 g of lactulose in three of the periods.