Publications by authors named "M Bashouti"
Article Synopsis
- Organophosphates (OP) are harmful chemicals used in agriculture and warfare, creating a need for effective detection methods that work quickly and are cost-effective, especially for detecting contamination in liquid samples.
- Current detection methods are only useful in the short term and fail to address long-term contamination risks, highlighting the need for real-time monitoring of OPs in water and soil.
- This study introduces a transistor-based sensor called MNChem, capable of ultra-sensitive, quantitative detection of diethyl cyanophosphonate (DCNP) in small liquid samples, achieving a detection limit of 100 fg/mL and a wide dynamic range, suggesting it’s suitable for on-site environmental analysis.*
Article Synopsis
- Transistor-based biosensing (BioFET) is explored as a promising method for future medical diagnostics but faces challenges with solution gating, as standard measurements affect the equilibrium of double layers where biomolecules interact.
- The study investigates a new BioFET design that separates the solution potential from the current gating process, allowing electrochemical equilibrium to be maintained while measuring biomolecule interactions.
- Results show that this decoupled approach significantly improves sensing performance for detecting ferritin in diluted plasma, achieving high sensitivity and a wide dynamic range compared to traditional methods.
Article Synopsis
- - The study focuses on using field-effect meta-nano-channel biosensors (MNC biosensors) to detect N-acetyl-beta-D-glucosaminidase (NAGase), an enzyme linked to infections in milk cows, in very small samples like 0.5 μL drops of milk.
- - The biosensor achieves highly specific and label-free sensing of NAGase with an impressive detection limit of 30.3 aM, spanning a dynamic range of eleven orders of magnitude, indicating strong linearity and sensitivity.
- - Two main findings highlight that despite the expected limitations due to the ionic strength and non-specific protein interactions in milk, the sensor works effectively, suggesting more research is needed on how non-specific
Achieving reliable and quantifiable performance in large-area surface-enhanced Raman spectroscopy (SERS) substrates poses a formidable challenge, demanding signal enhancement while ensuring response uniformity and reproducibility. Conventional SERS substrates often made of inhomogeneous materials with random resonator geometries, resulting in multiple or broadened plasmonic resonances, undesired absorptive losses, and uneven field enhancement. These limitations hamper reproducibility, making it difficult to conduct comparative studies with high sensitivity.
View Article and Find Full Text PDFAntibody-antigen interactions are shaped by the solution pH level, ionic strength, and electric fields, if present. In biological field-effect transistors (BioFETs), the interactions take place at the sensing area in which the pH level, ionic strength and electric fields are determined by the Poisson-Boltzmann equation and the boundary conditions at the solid-solution interface and the potential applied at the solution electrode. The present study demonstrates how a BioFET solution electrode potential affects the sensing area double layer pH level, ionic strength, and electric fields and in this way shapes the biological interactions at the sensing area.
View Article and Find Full Text PDF