Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds.

In biomaterial-based bone tissue engineering, optimizing scaffold structure and composition remains an active field of research. Additive manufacturing has enabled the production of custom designs in a variety of materials. This study aims to improve the design of calcium-phosphate-based additively manufactured scaffolds, the material of choice in oral bone regeneration, by using a combination of in silico and in vitro tools.

Coupling biomechanical models of implants with biodegradation models: A case study for biodegradable mandibular bone fixation plates.

In fracture fixation, biodegradable implant materials are an interesting alternative to conventional non-biodegradable materials as the latter often require a second implant removal surgery to avoid long-term complications. In this study, we present an in silico strategy to design/study biodegradable metal implants focusing on mandibular fracture fixation plates of WE43 (Mg alloy). The in silico strategy is composed of an orchestrated interaction between three separate computational models.

Image-based flow simulation of platelet aggregates under different shear rates.

Hemodynamics is crucial for the activation and aggregation of platelets in response to flow-induced shear. In this paper, a novel image-based computational model simulating blood flow through and around platelet aggregates is presented. The microstructure of aggregates was captured by two different modalities of microscopy images of in vitro whole blood perfusion experiments in microfluidic chambers coated with collagen.

Grain yield and micronutrient concentrations of maize parental lines of new hybrid genotypes affected by the foliar application of micronutrients.

Unlabelled: It is important for the breeders to find how genetic differences may affect crop grain yield and nutrient uptake affected by micronutrient fertilization. Accordingly, with respect to our published research, the foliar application of the most deficient micronutrients (Fe, Zn and Mn) in the arid and semi-arid areas of the world affecting grain yield and nutrient concentration of maize parental lines of new hybrid genotypes was tested in a two-year experiment (2016-2017). A split plot experiment (randomized complete block design) with seven maize parental lines (G1-G7, sub-plots), and eight micronutrients treatments (main plots) including control (without spraying, M1), Zn (M2), Mn (M3), and Fe (M4) at 3 g L, Mn + Zn (M5), Fe + Zn (M6), Fe + Mn (M7), and Fe + Mn + Zn (M8) at 1.

Melatonin effectiveness in amelioration of oxidative stress and strengthening of antioxidant defense system: Findings from a systematic review and dose-response meta-analysis of controlled clinical trials.

Background And Aim: Oxidative stress is involved in the development of chronic diseases. It has been suggested that melatonin has a protective role against oxidative stress by activation of antioxidant enzymes and scavenging free-radicals. Present study aimed to investigate the effect of melatonin supplementation on oxidative stress and antioxidant biomarkers such as malondialdehyde (MDA), increased total antioxidant capacity (TAC), superoxide dismutase (SOD), and Glutathione peroxidase (GPx).