Publications by authors named "M Barten"

Introduction: Psychosocial distress and mental health problems are common in patients before and after solid organ transplantation and can negatively affect morbidity, mortality, and adherence. Even though regular screening is recommended to identify patients with high levels of distress, the implementation in routine care has been insufficient so far.

Methods: Two newly developed problem lists for patients before and after transplantations were pilot implemented for 8 weeks at the Medical Center Hamburg Eppendorf (UKE) to identify factors facilitating and impeding their implementation.

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The Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology established the second consensus report to guide therapeutic drug monitoring (TDM) of everolimus (EVR) and its optimal use in clinical practice 7 years after the first version was published in 2016. This version provides information focused on new developments that have arisen in the last 7 years. For the general aspects of the pharmacology and TDM of EVR that have retained their relevance, readers can refer to the 2016 document.

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Article Synopsis
  • There is a pressing need for better treatments to prevent and manage allograft rejection in organ transplantation, as current immunosuppressive therapies come with significant side effects.
  • Extracorporeal photopheresis (ECP) is recommended as an adjunctive therapy for preventing organ rejection, especially in heart and lung transplants, and is being explored for kidney and liver transplants.
  • ECP shows promise as it may provide immunomodulation while reducing the reliance on traditional immunosuppression, particularly benefiting high-risk patients with additional health complications.
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Objectives: There are several surgical approaches for explanting a left ventricular assist device (LVAD) after recovery of cardiac function. Thus, remaining ventricular assist device components may bear significant risks of infection or thrombosis. We hereby report our technique and two-center experience with explantation of LVADs using a new double-patch technique.

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