Publications by authors named "M Barrot"
Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant ketamine. Selective Bmal1KO in CaMK2a excitatory neurons revealed that the functional mPFC clock is an essential factor for the development of a depression-like phenotype and ketamine effects.
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- - Researchers studied the connection between chronic pain and depression in mice, finding that a specific neuronal pathway linking the basolateral amygdala and anterior cingulate cortex is crucial for developing depression related to chronic pain.
- - Activation of this pathway in healthy mice not experiencing pain can still induce depressive-like behaviors and disrupt gene activity similar to what's seen in human depression, particularly affecting myelination-related genes.
- - The study highlights the importance of the amygdalo-cingulate pathway in the link between pain and depression, identifying Sema4a as a key factor in emotional issues and signaling irregular myelination processes that affect mood stability.
The voltage-gated sodium channel Nav1.7 is encoded by gene and plays a critical role in pain sensitivity. Several gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation.
View Article and Find Full Text PDFRole of the striatal dopamine, GABA and opioid systems in mediating feeding and fat intake.
Neurosci Biobehav Rev
August 2022
Article Synopsis
- Food intake is essential for survival but excessive consumption of fat and sugar can lead to obesity, a growing health concern.
- The enjoyment derived from eating, especially from high-fat and high-sugar foods, activates pleasure centers in the brain, particularly the striatal complex and mesolimbic dopamine system.
- This review explores how feeding affects various receptors and neurotransmitters in the brain, focusing on how these neurochemical systems influence the intake of palatable foods.
The tail of the ventral tegmental area (tVTA) or rostromedial tegmental nucleus (RMTg) receives lateral habenula inputs and projects heavily to midbrain dopamine neurons. Midbrain dopamine and lateral habenula neurons participate in learning processes predicting the outcomes of actions, placing the tVTA in a critical location into prediction error pathways. tVTA GABA neurons show electrophysiological inhibition or activation after reward and aversive stimuli, respectively, and their predictive cues.
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