Publications by authors named "M Barraclough"
Article Synopsis
- - The study aimed to update the 1998 Systemic Lupus Erythematosus (SLE) Core Outcome Set by evaluating existing domains and generating new ones, involving both patients and collaborators in the process.
- - A survey collected responses from 100 patients and 145 collaborators, revealing that patients focused on life-impact domains while collaborators emphasized clinical aspects, highlighting a need for balanced input from both groups.
- - Findings showed agreement on some domains for inclusion in the updated SLE Core Outcome Set, while also identifying areas that need more explanation and suggesting new domains for consideration.
Article Synopsis
- The study aims to identify distinct groups based on symptom intensity (fatigue, anxiety, depression, etc.) in patients with Systemic Lupus Erythematosus (SLE) and observe changes over a year.
- Results showed three symptom intensity clusters: mild, moderate, and severe, with varying stability; 49% of patients remained in their initial cluster after one year, particularly those in the mild cluster (77%).
- The findings suggest that patients in moderate symptom clusters could benefit from interventions to better manage their symptoms and potentially prevent deterioration to severe levels.
Post-COVID Syndrome has emerged as a significant public health concern worldwide with increasing evidence to suggest that individuals who have had an acute COVID-19 infection report lingering memory and attention difficulties, even in individuals who have fully recovered and no longer experiencing symptoms of COVID-19. The present study sought to investigate the profile of objective and subjective cognitive difficulties in people who have Post-COVID Syndrome, people who have fully recovered from an acute COVID infection and people who have never had COVID-19. We further sought to explore the extent to which self-reported fatigue and stress are related to subjective and objective cognitive difficulties.
View Article and Find Full Text PDFObjective: Cognitive impairment (CI) is one of the most common manifestations of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE). Despite its frequency, we have a limited understanding of the underlying immune mechanisms, resulting in a lack of pathways to target. This study aims to bridge this gap by investigating differences in serum analyte levels in SLE patients based on their cognitive performance, independently from the attribution to SLE, and exploring the potential for various serum analytes to differentiate between SLE patients with and without CI.
View Article and Find Full Text PDFObjective: Cognitive impairment (CI) in systemic lupus erythematosus (SLE) negatively impacts health-related quality of life leading to activity limitations. This qualitative study aimed to (1) explore the effect of SLE-related CI on activities of daily living and life role participation and (2) describe factors influencing activity restriction and life role participation.
Methods: Semistructured, in-depth interviews of lived experience of CI in SLE were conducted with 24 participants with SLE.