A radiolabelled iodobenzamide for malignant melanoma staging.

123I-N-(di-ethylamino-2-ethyl) 4 iodobenzamide (I-BZA) has been put forward by the Clermont-Ferrand INSERM U71 group (France) as a tracer for malignant melanoma. We report on the clinical results obtained in 56 studies performed on 48 patients. Whole body scans along with spot views were obtained after injection of 185 MBq of I-BZA.

Disseminated pagetoid reticulosis associated with mycosis fungoides: immunomorphologic study.

We report a 77-year-old woman with erythrosquamous plaques on the legs for 10 years. Biopsies taken 4 years ago revealed a pagetoid reticulosis with a massive epidermal cell infiltrate. She has now also developed a typical tumor of mycosis fungoides.

In vitro study of the cell populations in two cases of Kaposi's sarcoma.

Despite numerous studies, the histogenesis of Kaposi's sarcoma remains unclear. In connection with the culture of two Kaposi's sarcomas, the morphological, ultrastructural, and immunological properties of the various cell types observed are discussed. Cloning in agar, loss of contact inhibition, and karyotyping were used to determine which cells had undergone malignant transformation.

[Cutaneous apudoma. Apropos of a case and review of the literature].

It has been suggested that Merkel Ranvier cells, generally considered as belonging to the Apud system, may be the origin of extremely rare skin tumors. The authors analyse the characteristics of an apudoma in connexion with a case, and compare their findings with those of 58 other cases reported in the literature. With light microscopy techniques, the differential diagnosis is essentially one of a non-differentiated primary or secondary carcinoma, or of a lymphosarcoma.

[Cutaneous neuroendocrine carcinoma : apropos of a case].

A case of neuroendocrine carcinoma (Merkel cell tumor) of the skin in a 76 years old woman is reported. The lesion, an erythematous nodule, 2 to 3 cm in diameter occurred on the face. Light microscopic examination showed sheets of indifferentiated cells that had a uniform round nucleus and scanty cytoplasm containing argyrophil granules.