Dupilumab in chronic rhinosinusitis with nasal polyposis and concomitant cystic fibrosis: a real-life experience.

Purpose: Chronic rhinosinusitis (CRS) has been distinguished in primary CRS, a primary inflammatory disorder limited to airways and secondary CRS, in which the sinonasal pathology is caused by a systemic disease or a local pathologic condition. Primary CRS is in turn classified in Type 2 and Non-type 2 on the basis of the endotype and of the pattern of the immune response. Advance in the knowledge of CRS has led to new therapeutic options, among which Dupilumab (anti-IL4R).

Silicone deposition and adverse pulmonary events secondary to breast implant rupture.

Silicone breast implants are common but may be associated with a number of complications including implant rupture. This case reports a 38-year-old woman with bilateral breast implants who presented with breast unevenness, triggering a cascade of investigations that identified implant rupture. A computed tomography scan of the thorax showed subpleural enhancing nodules in the left lung of equal density as the implants, repeat computed tomography thorax months later showed no interval changes.

Helical coil design with controlled dispersion for bunching enhancement of protons generated by the target normal sheath acceleration.

The quality of the proton beam produced by target normal sheath acceleration (TNSA) with high-power lasers can be significantly improved with the use of helical coils. While they showed promising results in terms of focusing, their performances in terms of the of cut-off energy and bunching stay limited due to the dispersive nature of helical coils. A new scheme of helical coil with a tube surrounding the helix is introduced, and the first numerical simulations and an analytical model show a possibility of a drastic reduction of the current pulse dispersion for the parameters of high-power-laser facilities.

Value and role of surgical margins in transoral laser microsurgery of the larynx, literature review and clinical considerations.

Purpose: There is no agreement on the most appropriate post-operative pathway for the management of positive margins after laser cordectomy for early stage glottic tumours (T1-2N0M0). This literature review and meta-analysis aim to evaluate the post-operative treatment with the best oncological results among follow-up, radiotherapy (RT) and surgical second look. The parameters utilized were incidence of recurrence, overall (OS), disease-specific (DSS) and disease-free (DFS) survival and larynx preservation (LP).

Synthesis, bioevaluation and docking studies of some 2-phenyl-1H-benzimidazole derivatives as anthelminthic agents against the nematode Teladorsagia circumcincta.

Gastrointestinal nematode infections are the main diseases in herds of small ruminants. Resistance to the main established drugs has become a worldwide problem. The purpose of this study is to obtain and evaluate the in vitro ovicidal and larvicidal activity of some 2-phenylbenzimidazole derivatives on susceptible and resistant strains of Teladorsagia circumcincta.