Publications by authors named "M Barczewska"
Current treatments of degenerated intervertebral discs often provide only temporary relief or address specific causes, necessitating the exploration of alternative therapies. Cell-based regenerative approaches showed promise in many clinical trials, but limitations such as cell death during injection and a harsh disk environment hinder their effectiveness. Injectable microscaffolds offer a solution by providing a supportive microenvironment for cell delivery and enhancing bioactivity.
View Article and Find Full Text PDFThe use of injectable biomaterials for cell delivery is a rapidly expanding field which may revolutionize the medical treatments by making them less invasive. However, creating desirable cell carriers poses significant challenges to the clinical implementation of cell-based therapeutics. At the same time, no method has been developed to produce injectable microscaffolds (MSs) from electrospun materials.
View Article and Find Full Text PDFBACKGROUND The aim of this study was to investigate repeated intrathecal injection of autologous bone marrow-derived mesenchymal stem cells (BM-D MSCs) to patients for treatment of sporadic amyotrophic lateral sclerosis (ALS). MATERIAL AND METHODS Autologous MSCs were isolated from the patients' bone marrow, plated, expanded, harvested, and passaged. Stem cells from a single bone marrow collection were used for 3 injections per patient, given over a 3-month period.
View Article and Find Full Text PDFObjective: Amyotrophic lateral sclerosis (ALS) is still incurable. Although different therapies can affect the health and survival of patients. Our aim is to evaluate the effect of umbilical mesenchymal stem cells administrated intrathecally to patients with amyotrophic lateral sclerosis on disability development and survival.
View Article and Find Full Text PDFArticle Synopsis
- Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease with limited treatment options, and patients often experience depression and anxiety, impacting their therapy adherence.
- This study evaluated a patient with ALS who had stem cell transplantation and initially refused physiotherapy due to depression, then tracked their progress over 12 months after starting a tailored rehabilitation program.
- Results showed significant improvements in neuromuscular function and respiratory capacity, suggesting that integrating neurofeedback into rehabilitation could effectively support ALS patients' therapy and overall well-being.*