Publications by authors named "M Barchuk"
Background And Aims: Glucagon-like peptide-1 (GLP-1) analogues reduce body fat and cardiovascular events in patients with type 2 diabetes. Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and coronary events in type 2 diabetes.
Methods: A systematic review and meta-analysis were performed from Glucagon-like peptide-1 analogues therapy on type 2 diabetes patients, reporting data from changes in EAT, after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases.
Background: Epicardial adipose tissue (EAT) contributes to coronary artery disease (CAD). EAT presents a specific lipidomic signature, showing increased ceramides and other proinflammatory lipids content. Besides, LPL (lipoprotein lipase) activity in EAT would contribute to its expansion, supplying fatty acids to the tissue.
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- The study examined bioremediation methods for polychlorinated biphenyls (PCBs) in soil using three strategies: mycoaugmentation with specific fungi, biostimulation with sugarcane bagasse, and natural attenuation without amendments.
- Both mycoaugmentation and biostimulation showed significant effectiveness, removing approximately 90% of PCBs and reducing toxicity in the soil over 90 days.
- The results indicated that sugarcane bagasse serves as an effective support for fungal growth and improves soil quality while highlighting mycoaugmentation and biostimulation as viable solutions for cleaning up PCB-contaminated soils.
Article Synopsis
- Coronary artery disease (CAD) is a major health issue globally, with triglyceride-rich lipoproteins potentially increasing CAD risk, influenced by enzymes like lipoprotein lipase (LPL) and endothelial lipase (EL) along with the surrounding epicardial adipose tissue (EAT).
- The study involved analysis of serum and tissue samples from patients undergoing heart surgeries to assess levels of LPL, EL, and related proteins, comparing those with and without coronary artery bypass grafting (CABG).
- Findings showed that while LPL levels decreased and EL levels increased in CABG patients, GPIHBP1 and Apoprotein levels showed different patterns, suggesting EAT's limited role in circulating enzyme levels related to
Objective: Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through the paracrine release of proatherogenic mediators. Numerous works have analyzed the inflammatory signature of EAT, but scarce informations on its lipidome are available. Our objective was first to study the differences between EAT and subcutaneous adipose tissue (SAT) lipidomes and second to identify the specific untargeted lipidomic signatures of EAT and SAT in CAD.
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