Publications by authors named "M Barbeau"
Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the maturation of the host response against controlled repeat exposures to P. falciparum (Pf) NF54 strain-infected mosquitoes, we systematically monitored malaria-naïve participants through an initial exposure to uninfected mosquitoes and 4 subsequent homologous exposures to Pf-infected mosquitoes over 21 months (n = 8 males) (ClinicalTrials.
View Article and Find Full Text PDFUnlabelled: The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) plays a key role in tumor progression and response to therapy. The dense PDAC stroma causes hypovascularity, which leads to hypoxia. Here, we showed that hypoxia drives long-lasting epithelial-mesenchymal transition (EMT) in PDAC primarily through a positive-feedback histone methylation-MAPK signaling axis.
View Article and Find Full Text PDFBackground: Toenail onychomycosis affects approximately 6.7% of Canadians. Symptoms include nail discolouration/disfiguration and pain; psychosocial impacts contribute to reduced health-related quality-of-life.
View Article and Find Full Text PDFBackground: There is limited real-life evidence with brodalumab in patients with plaque psoriasis in Canada.
Objectives: To examine real-world effectiveness of brodalumab in Canadian routine care with a focus on clinician and patient-reported outcomes, as well as measuring continuation rates and persistency.
Methods: Retrospective analysis was conducted on data collected through the brodalumab patient support program (PSP) in Canada for patients initiating brodalumab between June 2018 (PSP launch)- June 2020 with a minimum of 16 weeks follow-up from first dose.
Article Synopsis
- Protists are critical yet underexplored microorganisms that play essential roles in nutrient and energy cycling, especially in marine environments like the Bay of Fundy mudflats.
- A study using 18S rDNA metabarcoding revealed three dominant protist lineages (Cercozoa, Bacillariophyta, and Dinophyceae) that significantly influence community dynamics and structure in these sediments.
- Findings indicate that the interactions between local and regional processes, including benthic-pelagic coupling, drive the diverse microbial distribution in high-energy coastal ecosystems.