Publications by authors named "M Barale"
Article Synopsis
- The study examines the cardiometabolic effects of hypercalcemic primary hyperparathyroidism (HC-PHPT) compared to normocalcemic primary hyperparathyroidism (NC-PHPT) and controls.
- Patients with HC-PHPT exhibited significant cardiometabolic abnormalities, including higher glucose, cholesterol, and blood pressure levels, as well as more frequent cardiovascular events compared to both NC-PHPT patients and controls.
- The findings suggest that NC-PHPT does not show these cardiovascular issues, indicating that hypercalcemia may play a key role in the development of cardiometabolic disorders in HC-PHPT.
Article Synopsis
- Fabry disease (FD) is a genetic disorder that increases osteoporosis and fracture risk, and the study aimed to assess how it affects bone quality, specifically trabecular bone microarchitecture.
- The study compared 14 newly diagnosed FD patients to 42 control subjects, measuring factors like bone mineral density (BMD) and trabecular bone score (TBS) using DXA imaging.
- Results showed FD patients had significantly lower TBS and BMD, higher levels of parathyroid hormone, and FD was identified as a risk factor for reduced bone quality.
Pituitary hormones play a crucial role in regulating skeletal physiology, and skeletal fragility is a frequent complication of pituitary diseases. The ability to predict the risk of fracture events is crucial for guiding therapeutic decisions; however, in patients with pituitary diseases, fracture risk estimation is particularly challenging. Compared to primary osteoporosis, the evaluation of bone mineral density by dual X-ray absorptiometry is much less informative about fracture risk.
View Article and Find Full Text PDFContext: Chronic use of proton pump inhibitors (PPIs) has been associated with an increase in bone fragility. However, evidence on the effect of chronic PPI use on bone density is conflicting, and data on bone microarchitectural quality are scarce.
Objective: The primary aim of this study was to evaluate whether trabecular bone microarchitecture, assessed by trabecular bone score (TBS), is altered in chronic PPI users.
Minimally invasive transperitoneal partial versus radical nephrectomy in obese patients: perioperative and long-term functional outcomes from a large perspective contemporary series (RECORd2 project).
Minerva Urol Nephrol
April 2024
Article Synopsis
- - This study analyzes outcomes of laparoscopic (LPN), robot-assisted (RAPN), and laparoscopic radical nephrectomy (LRN) in obese patients with renal cell carcinoma to assess their perioperative and long-term effectiveness.
- - Data from 388 patients were evaluated, showing that LRN resulted in a significantly higher incidence of acute kidney injury and greater decline in renal function compared to LPN and RAPN.
- - The research suggests that LPN and RAPN are associated with similar complication rates and better kidney function preservation than LRN, emphasizing the advantages of these minimally invasive techniques for obese patients.