Publications by authors named "M Ballent"
Article Synopsis
- The study aimed to investigate how smoking exposure is linked to organ damage in patients with systemic lupus erythematosus (SLE) using a specific damage score (SLICC-SDI) in an Argentinian cohort.
- Out of 623 SLE patients analyzed, 84% were non-smokers, while 16% were current smokers, with 17% showing severe organ damage (SLICC-SDI ≥3).
- The findings indicated that current smoking, older age, longer disease duration, and the use of cyclophosphamide are significantly associated with severe organ damage in SLE patients.
Improvement in the use of existing anthelmintics is a high priority need for the pharmaco-parasitology research field, considering the magnitude and severity of anthelmintic resistance as an important issue in livestock production. In the work described here, monepantel (MNP) was given alone or co-administered with either macrocyclic lactone (ML) or benzimidazole (BZ) anthelmintics to calves naturally infected with ML- and BZ-resistant gastrointestinal (GI) nematodes on two different commercial cattle farms. Both pharmacokinetic (PK) and efficacy assessments were performed.
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- Mammalian ABC transporters play a crucial role in regulating cellular levels of various substances and are linked to drug resistance, specifically observed in the sheep nematode Haemonchus contortus regarding ivermectin (IVM).
- The study aimed to analyze the gene expression of the entire ABC-transporter family in H. contortus isolates that vary in their susceptibility to IVM and to assess the impact of IVM treatment on resistant isolates.
- Results showed minor expression differences in certain ABC genes, but only HCON_00130060 (pgp-9.2) was significantly different in expression levels between resistant and susceptible isolates, suggesting it may play a key role in IVM resistance.
This study aimed at determining the plasma disposition kinetics of eprinomectin (EPM) and EPM excretion pattern through milk after topical administration to dairy cattle at the recommended dose of 0.5 mg/kg and at 1 and 1.5 mg/kg.
View Article and Find Full Text PDFThe goal of the current work was to perform an integrated evaluation of monepantel (MNP) pharmacokinetics (PK) and pharmacodynamics, measured as anthelmintic efficacy, after its oral administration to calves naturally infected with GI nematodes resistant to ivermectin (IVM) and ricobendazole (RBZ) on three commercial farms. On each farm, forty-five calves were randomly allocated into three groups (n = 15): MNP oral administration (2.5 mg/kg); IVM subcutaneous (SC) administration (0.
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