-Hydroxyurea (HU) is an important chemotherapeutic agent used as a first-line treatment in conditions such as sickle cell disease and β-thalassemia, among others. To date, its properties as a hydrated molecule in the blood plasma or cytoplasm are dramatically understudied, although they may be crucial to the binding of HU to the radical catalytic site of ribonucleotide reductase, its molecular target. The purpose of this work is the comprehensive exploration of HU hydration.
View Article and Find Full Text PDFAim: The aim of the study was to analyse the prescribing pattern of antipsychotic drugs in patients with schizophrenia during the years 2013-2018.
Method: Schizophrenia is analysed as one of the diseases with the highest rate of Disability-Adjusted Life Years - DALY. In this study, the unitary data of the National Health Fund (NFZ) reported in the years 2013-2018 were used.
Aim.: Analysis of psychiatric services for patients diagnosed with schizophrenia, reported to the National Health Fund in the years 2009-2018.
Material And Methods: Schizophrenia is analyzed as one of the diseases with the highest rate of Disability-Adjusted Life Years - DALY.
Objectives: The aim of the presented research is to characterize the operating Mental Health Centers (MHCs) and to provide a preliminary assessment of the implementation process of the pilot program model in the area of psychiatric care in Poland.
Methods: The study uses the Polish version of the German questionnaire, which covers four areas: (1) basic conditionsof the model project/pilot program; (2) characteristicsof the organizational structure of the treatment entity; (3) statistical characteristics of the services provided;(4) specific features of the psychiatric care system in model regions/pilot program Mental Health Centers.
Results: Nineteen of the 27 Mental Health Centers completed the survey.