Ndrg3 is a critical regulator of peripheral T cell maturation and homeostasis.

To provide protection, anticipatory T cell-dependent immunity is reliant on the generation and maintenance of a naïve T cell repertoire, which is sufficiently diverse to ensure recognition of newly encountered antigens. Therefore, under steady-state conditions, a given individual needs to maintain a large pool of naïve T cells, ready to respond to potential threats. Here, we demonstrate that N-myc downstream-regulated gene 3 (Ndrg3) is essential for naïve T cell stability.

Recycled Aluminum Paraffin Composite for Passive Cooling Application in Buildings.

This paper presents a new composite phase change material made of paraffin and recycled aluminum sawing chips. Aluminum sawing chips were selected as a thermal conductivity enhancer, the volume fraction (~15%) of which, in the paraffin composite material, was minimized by selecting a fraction with shape that minimizes its packing density. Therefore, the particles remained in contact inside the composite, and thus, their sinking in the liquid state was avoided.

The green ICU: how to interpret green? A multiple perspective approach.

Mitigating environmental impacts is an urgent challenge supported by (scientific) intensive care societies worldwide. However, making green choices without compromising high-quality care for critically ill patients may be challenging. The current paper describes a three-step approach towards green intensive care units.

Novel endpoints based on tumor size ratio to support early clinical decision-making in oncology drug-development.

In oncology drug development, overall response rate (ORR) is commonly used as an early endpoint to assess the clinical benefits of new interventions; however, ORR benefit may not always translate into a long-term clinical benefit such as overall survival (OS). Most of the work on developing endpoints based on tumor growth dynamics relies on empirical validation, leading to a lack of generalizability of the endpoints across indications and therapeutic modalities. Additionally, many of these metrics are model-based and do not use data from all the patients.