Publications by authors named "M Balado"
First complete genome sequence of serotype O4, a rising threat in marine aquaculture.
Microbiol Resour Announc
December 2024
is a Gram-negative marine fish pathogen. Here, we present the complete genome sequence of strain SP9.1, representing the emerging serotype O4.
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- The study discovered a new genomic island (pddGI-1) in the marine pathogen Photobacterium damselae, located on chromosome II.
- This genomic island shares features with other islands in Vibrio species and consists of genes for antioxidant defense, energy metabolism, and systems that modify DNA.
- The pddGI-1 also includes a complete system for vibroferrin, which helps the bacteria thrive in low-iron environments, suggesting that strains with this island have a growth advantage in such conditions.
Outer membrane vesicles (OMVs) have been gained increasing attention in vaccinology due to their ability to induce strong protective humoral and cell-mediated immunity. The Gram-negative bacterium Tenacibaculum maritimum, the causative agent of marine tenacibaculosis, poses a significant challenge to the global aquaculture industry due to its difficult prophylaxis. In previous studies, we demonstrated that OMV production is a key virulence mechanism in T.
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- Photoxenobactin E is a natural product derived from an insect-pathogenic bacterium, featuring a unique thiocarboxylic acid structure and related to the biosynthesis of piscibactin, which helps bacteria acquire iron.
- The study highlights the reisolation of photoxenobactin E from the fish pathogen RV22 and demonstrates its ability to chelate Ga(III) ions, along with detailed NMR characterization of the resulting complex.
- The research reveals that the Ga(III)-photoxenobactin E complex exists in a dynamic tautomeric equilibrium, providing insights into how the thiocarboxylate group can effectively bind to hard metal ions, which is important for future ligand design.
The high-pathogenicity island -HPI is widespread in and encodes the siderophore piscibactin, as well as the regulator PbtA that is essential for its expression. In this work, we aim to study whether PbtA directly interacts with -HPI promoters. Furthermore, we hypothesize that PbtA, and thereby the acquisition of -HPI island, may also influence the expression of other genes elsewhere in the bacterial genome.
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