Generation of O and O from Endoperoxides for *O-Labeling and Mechanistic Studies of Oxidations by Dioxygen.

Near-stoichiometric amounts of O and O were generated from endoperoxides in a two-chamber glassware to oxidize various substrates. This strategy gave [*O]endoperoxides, [*O]quinones, [*O]phenols, and [*O]artemisin in moderate to good yields and high isotopic enrichments (up to 84%) at affordable costs. Moreover, mass spectrometry and O NMR of the [*O]products provided valuable information about the chemical mechanisms involved.

Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age.

Dacarbazine is commonly administered for the treatment of cancers prevalent in reproductive age females. However, investigations of off-target effects of dacarbazine on the ovary are limited. We assessed the impact of dacarbazine on the ovarian reserve of primordial follicles, essential for fertility.

[Clinical biological features of mixed myeloid diseases].

Aim: To characterize patients with mixed myeloid neoplasias with proliferation of neutrophils, platelets and eosinophils.

Material And Methods: Examination and treatment results were analysed for patients with atypical myeloid leukemia (n = 4), myelodysplastic syndrome (MDS, n = 1) and thrombocytosis, MDS and eosinophilia (n = 1). The examination included morphological, histological, cytogenetic and molecular tests.

[Immunosuppression induced by respiratory viruses (influenza virus, adenovirus) in mice].

The influence of respiratory viruses (adenovirus, influenza virus) on humoral immune response to heterologous T-dependent and T-independent antigens was studied. It was shown that inoculation of mice by the influenza virus (A/PR8/34-A/PR/8) 3 days before sheep red blood cells administration led to the inhibition of antibody forming cell (AFC) and immunoglobulin, forming cell (IFC) increase on 69% and 59% respectively. Adenovirus type 6 induced the similar suppression of AFC and IFC formation.