Publications by authors named "M Bagnoli"
Background: Ovarian cancer (OvC) constitutes significant management challenges primarily due to its late-stage diagnosis and the development of resistance to chemotherapy. The standard treatment regimen typically includes carboplatin and paclitaxel, with the addition of poly (ADP-ribose) polymerase inhibitors for patients with high-grade serous ovarian cancer (HGSOC) harboring BRCA1/2 mutations. However, the variability in treatment responses suggests the need to investigate factors beyond BRCA1/2 mutations, such as DNA repair mechanisms and epigenetic alterations.
View Article and Find Full Text PDFWearable devices as part of postoperative early warning score systems: a scoping review.
J Clin Monit Comput
October 2024
Article Synopsis
- Postoperative deterioration can be indicated by changes in vital signs, but many hospitals lack resources for continuous monitoring outside of ICUs, prompting the use of wearable devices (WDs) for patient monitoring.
- A Scoping Review was conducted using various databases to analyze the effectiveness of WDs as part of Continuous Remote Early Warning Score (CREWS) systems in monitoring patients after cardiac and non-cardiac surgeries, resulting in 10 studies featuring 11 CE/FDA approved devices.
- The findings suggest that WDs are not only feasible and safe for monitoring but also help reduce the length of hospital stays and ICU admissions, leading to lower healthcare costs and better identification of potential complications post-surgery
Cholelithiasis and its complications are among the most prevalent and costly medical conditions in the United States. Chronic gallbladder disease can progress into more complicated conditions, such as a cholecystoenteric fistula and, more specifically, a cholecystoduodenal fistula (CDF). Repair of these fistulas is complex and usually performed with an open approach.
View Article and Find Full Text PDFArticle Synopsis
- Proton magnetic resonance spectroscopy (H-MRS) can help study cancer metabolism and the relevance of the "total choline" peak as a marker for malignancy and treatment response.
- Standardized procedures for handling tumor specimens are crucial to preserve metabolomic information, particularly evaluating the effects of cold ischemia time.
- The study found that a maximum delay of 1 hour before freezing clinical ovarian cancer specimens maintained reliable choline profiles, while longer times can lead to significant metabolite changes.
Background: Validated prognostic biomarkers for anti-angiogenic therapy using the anti-VEGF antibody Bevacizumab in ovarian cancer (OC) patients are still an unmet clinical need. The EGFR can contribute to cancer-associated biological mechanisms in OC cells including angiogenesis, but its targeting gave disappointing results with less than 10% of OC patients treated with anti-EGFR compounds showing a positive response, likely due to a non adequate selection and stratification of EGFR-expressing OC patients.
Methods: EGFR membrane expression was evaluated by immunohistochemistry in a cohort of 310 OC patients from the MITO-16A/MANGO-OV2A trial, designed to identify prognostic biomarkers of survival in patients treated with first line standard chemotherapy plus bevacizumab.