Publications by authors named "M Baetens"
Article Synopsis
- Aberrant embryo implantation and placentation can lead to serious pregnancy complications like preeclampsia, and current risk identification methods are not very accurate.
- The ExPECT study aims to validate a cell-free DNA methylation strategy to diagnose preeclampsia early and identify high-risk pregnancies by analyzing blood samples over time.
- Results showed distinct methylation patterns between healthy and affected pregnancies, with significant differences detectable as early as 12 weeks, leading to the development of promising classification models for diagnosis and prediction.
Article Synopsis
- The study investigates how genotype analysis can enhance the classification of (mosaic) aneuploid embryos that have been diagnosed through copy number analysis of a trophectoderm biopsy.
- Results showed that genotype analysis can identify different types of aneuploidy, revealing meiotic or uniform aneuploidy in embryos with intermediate changes, and presumed mitotic or mosaic aneuploidy in those with full changes.
- The research involved a large-scale analysis of 1560 embryos, focusing on assessing the chromosomal anomalies and their origins by integrating copy number data with genotyping.
Article Synopsis
- The study investigates whether pronuclear transfer (PNT) can enhance embryo development in mouse oocytes that have been grown in vitro (IVG) but suffer from cytoplasmic deficiencies.
- Results show that using PNT with matured cytoplasm significantly improved the development of IVG oocytes, producing live and fertile offspring, suggesting a potential method to address fertility issues.
- Conducted from September 2020 to February 2022, this research involved 120 B6D2 mice and aimed to establish effective techniques for culture and maturation of ovarian follicles while comparing IVG oocytes to those grown in vivo.
Craniofacial abnormalities account for approximately one third of birth defects. The regulatory programs that build the face require precisely controlled spatiotemporal gene expression, achieved through tissue-specific enhancers. Clusters of coactivated enhancers and their target genes, known as superenhancers, are important in determining cell identity but have been largely unexplored in development.
View Article and Find Full Text PDFStudy Question: Can spindle transfer (ST) overcome inferior embryonic development of in vitro matured ovarian tissue oocytes (OTO-IVM) originating from testosterone-treated transgender men?
Summary Answer: ST shows some potential to overcome the embryo developmental arrest observed in OTO-IVM oocytes from transgender men.
What Is Known Already: OTO-IVM is being applied as a complementary approach to increase the number of oocytes/embryos available for fertility preservation during ovarian tissue cryopreservation in cancer patients. OTO-IVM has also been proposed for transgender men, although the potential of their oocytes remains poorly investigated.