Publications by authors named "M Baekvad-Hansen"
Background: Neonatal herpes simplex virus (HSV) infection is life-threatening, with a mortality of up to 70-80% when disseminated, often due to vague symptoms and delayed treatment. Neonatal screening using dried blood spot (DBS) samples is among the most impactful preventative health measures ever implemented, but screening for HSV has not been investigated.
Methods: We investigated high throughput multiplexed proteomics on DBS samples collected on days 2-3 of life from a nationwide cohort of neonates with HSV infection (n = 53) and matched controls.
Article Synopsis
- - ADHD is a neurodevelopmental disorder often identified in childhood, with both genetic and environmental risk factors influencing its development, including maternal infections during pregnancy.
- - A study measuring immune responses to various microorganisms in newborns found a significant association between higher antibody levels against cytomegalovirus (CMV) and mycoplasma with later ADHD diagnosis.
- - There is a suggested dose-response relationship indicating that increased immune system activation before or at birth may elevate the risk of ADHD, highlighting the need for healthy pregnancy practices to minimize infection risks.
Article Synopsis
- PTSD genetics have been difficult to study compared to other psychiatric disorders, limiting our biological understanding of the condition.
- A large-scale meta-analysis involving over 1.2 million individuals identified 95 genome-wide significant loci, with 80 being new discoveries related to PTSD.
- Researchers identified 43 potential causal genes linked to neurotransmitter activity, developmental processes, synaptic function, and immune regulation, enhancing our knowledge of the neurobiological systems involved in PTSD.
Introduction: The apolipoprotein E () ε4 allele is associated with high risk for Alzheimer's disease. It is unclear whether individual levels of the circulating apoE4 protein in ε4 carriers confer additional risk. Measuring apoE4 protein levels from dried blood spots (DBS) has the potential to provide information on genetic status as well as circulating levels and to include these measures in large survey settings.
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- EBV-associated T-cell and NK-cell lymphoproliferative diseases are rare and deadly, especially in Caucasians, with this study focusing on a 19-year-old boy diagnosed with systemic EBV positive T-cell lymphoma.
- The research highlights severe immune issues, including lympho-depletion and halted thymopoiesis, linked to heightened EBV and immune activation.
- A significant somatic missense variant in the proto-oncogene FYN was found, with a 48% variant allele frequency in this case, suggesting it may play a role in excessive T-cell activation and could be a potential target for future treatments.