Publications by authors named "M Badii"
Article Synopsis
- * Research focused on IL1RN rs9973741, highlighting that this gout risk allele (G) is associated with decreased production of the anti-inflammatory cytokine IL-1Ra after stimulation and increased IL-1β production in immune cells.
- * The findings suggest that the genetic variations in the IL1RN-IL1F10 locus influence how immune cells respond to MSU crystals, contributing to the inflammatory processes involved in gout.
Type I interferons (IFN1s) mediate innate responses to microbial stimuli and regulate interleukin (IL)-1 and IL-1 receptor antagonist (Ra) production in human cells. This study explores interferon-stimulated gene (ISG) alterations in the transcriptome of patients with gout and stimulated human primary cells in vitro in relation to serum urate concentrations. Peripheral blood mononuclear cells (PBMCs) and monocytes of patients with gout were primed in vitro with soluble urate, followed by lipopolysaccharide (LPS) stimulation.
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- Minimally invasive interventional radiology procedures assist in managing osteoarthritis (OA) symptoms to potentially delay total knee arthroplasty (TKA).
- Current intra-articular injections provide only temporary relief, prompting the development of new methods.
- Techniques like genicular artery embolization and genicular nerve ablation have shown promise in improving pain control and quality of life for those with mild-to-moderate OA, potentially serving as alternatives to traditional injections.
Article Synopsis
- Myo-inositol is elevated in patients with heart failure (HF), particularly in those with heart failure with preserved ejection fraction (HFpEF), and is associated with negative clinical outcomes.
- The study measured plasmatic myo-inositol levels in large cohorts from Belgium and Canada, revealing significant increases in HF patients compared to those without.
- Elevated myo-inositol levels correlate with worsening kidney function and cardiac markers, suggesting a potential role in the development and progression of HFpEF.
The mRNA vaccine against COVID-19 protects against severe disease by the induction of robust humoral and cellular responses. Recent studies have shown the capacity of some vaccines to induce enduring non-specific innate immune responses by the induction of trained immunity, augmenting protection against unrelated pathogens. This study aimed to assess whether the mRNA vaccine BNT162b2 can induce lasting non-specific immune responses in myeloid cells following a three-dose vaccination scheme.
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