Construction of a nomogram prediction model for early postoperative stoma complications of colorectal cancer.

Background: Postoperative enterostomy is increasing in patients with colorectal cancer, but there is a lack of a model that can predict the probability of early complications.

Aim: To explore the factors influencing early postoperative stoma complications in colorectal cancer patients and to construct a nomogram prediction model for predicting the probability of these complications.

Methods: A retrospective study of 462 patients who underwent postoperative ostomy for colorectal cancer in the Gastrointestinal Department of the Anhui Provincial Cancer Hospital.

Size-specific mediation of the physiological responses and degradation ability of microalgae to sulfamerazine by microplastics.

Antibiotics and microplastics (MPs) are two classes of emerging contaminants that are commonly found in various water environments. However, how different sized MPs affect the toxicity and biodegradation of antibiotics remains poorly understood. We investigated the effects of polystyrene (PS) MPs with different particle sizes (100 nm and 30 μm) on the physiological responses and degradation behavior of Phaeodactylum tricornutum to sulfamerazine (SMR).

Chronic Jet Lag Disrupts Circadian Rhythms and Induces Hyperproliferation in Murine Lacrimal Glands via ROS Accumulation.

Purpose: Chronic jet lag (CJL) is known to disrupt circadian rhythms, which regulate various physiological processes, including ocular surface homeostasis. However, the specific effects of CJL on lacrimal gland function and the underlying cellular mechanisms remain poorly understood.

Methods: A CJL model was established using C57BL/6J mice.

Leptin Receptor Deficiency-Associated Diabetes Disrupts Lacrimal Gland Circadian Rhythms and Contributes to Dry Eye Syndrome.

Purpose: This study investigated the impact of hyperglycemia in type 2 diabetes mellitus (T2DM) on the circadian rhythms and function of lacrimal glands (LGs) in contributing to dry eye syndrome. We assessed the effects of hyperglycemia on circadian gene expression, immune cell recruitment, neural activity, and metabolic pathways, and evaluated the effectiveness of insulin in restoring normal LG function.

Methods: Using a T2DM mouse model (db/db mice), circadian transcriptomic changes in LGs were analyzed through RNA sequencing over a 24-hour period.

Temperature influence on matric suction in unsaturated soils: experimental insights.

Temperature is a critical factor affecting the matric suction of unsaturated soils. This study employed a simple and time-saving method to investigate the influences of temperature and moisture content on the temperature dependence of matric suction in loess and sand soils. Based on experimental data, the fitting performance of three data-fitting models-Brooks-Corey, van Genuchten, and Fredlund-Xing -was evaluated at temperatures above 0 °C.