Publications by authors named "M BRECKWOLDT"
Article Synopsis
- Glioblastomas are aggressive brain tumors that resist treatment and utilize neuron-tumor connections to promote their growth, with cholinergic neurons playing a key role in this invasion.
- The study utilized rabies viruses for retrograde tracing to reveal how glioblastomas integrate into brain circuits, showing that radiotherapy can enhance neuron-tumor connectivity, complicating treatment efforts.
- By disrupting neuron-tumor connections, researchers discovered a potential therapeutic approach that could halt glioblastoma progression, emphasizing the need to target these synapses for better treatment outcomes.
Objectives: Recurrent glioma is highly treatment resistant due to its metabolic, cellular, and molecular heterogeneity and invasiveness. Tumor monitoring by conventional MRI has shortcomings to assess these key glioma characteristics. Recent studies introduced chemical exchange saturation transfer for metabolic imaging in oncology and assessed its diagnostic value for newly diagnosed glioma.
View Article and Find Full Text PDFIntroduction: Mechanical thrombectomy is a highly effective treatment for acute ischemic stroke (AIS) caused by large vessel occlusions (LVO). However, our understanding of the pathophysiology of AIS is still limited, particularly regarding the ischemic microenvironment distal to the occlusion.
Aim: To investigate the relationship between the intracerebral blood pressure (BP) distal to an LVO and clinical and imaging parameters.
Aim: Peripheral nerve scarring is a severe yet common complication following nerve injury or surgery that can lead to impaired nerve function, including chronic pain and sensory or motor deficits. In this study, we aimed to establish high-resolution magnetic resonance neurography (MRN) to accurately visualize and monitor de novo-formed epineural fibrotic adhesions (EFAs) of the sciatic nerve in a rat nerve injury model.
Methods: Employing an established model to induce overshooting EFA, the study included 3 experimental groups of animals (n = 6 each): a positive control group (PC), an intervention group (IG), and a sham group.
Article Synopsis
- Intravital 2P-microscopy facilitates the study of brain tumor behavior in mouse cortex, previously limited by imaging challenges in deep brain areas.
- The new Deep3P imaging workflow combines microscopy with artificial intelligence, allowing researchers to visualize glioblastoma infiltrating up to 1.2 mm into the brain.
- The study reveals that glioblastoma primarily invades through blood vessels in the white matter, and identifies potential imaging biomarkers associated with early tumor colonization.