Publications by authors named "M BONJEAN"
Article Synopsis
- Conducted whole-genome sequencing on 263 cholera O1 isolates from four provinces in the Democratic Republic of Congo between 2018 and 2024, identifying them as part of the AFR10 lineage.
- The study revealed that while core genomic changes were minimal, significant rearrangements in the CTX prophage were noted in recent isolates from 2022-2024.
- AFR10e showed widespread distribution across provinces, while AFR10d appeared to be extinct after 2020, highlighting important shifts in cholera strain characteristics.
Article Synopsis
- This study investigates multidrug-resistant (MDR) and extended spectrum β-lactamase (ESBL)-producing bacteria causing infections at a hospital in South-Kivu, DRC, highlighting their links to higher illness and death rates.
- Researchers performed whole-genome sequencing on 37 bacterial isolates, revealing significant genetic diversity, widespread antibiotic resistance, and the presence of various resistance genes but no carbapenemase genes.
- Findings emphasize the need to monitor both the genetic and phenotypic evolution of antibiotic resistance in the region and suggest caution in using colistin and carbapenems due to these resistance patterns.
Disk diffusion testing is widely used to detect methicillin resistance in staphylococci, and cefoxitin is currently considered the best marker for mecA-mediated methicillin resistance. In low-inoculum diffusion testing (colony suspension at 10 CFU/ml), the addition of moxalactam in combination with cefoxitin has been reported to improve on cefoxitin alone for the detection of methicillin-heteroresistant staphylococci. However, moxalactam is absent from EUCAST and CLSI guidelines, which use high-inoculum diffusion testing (colony suspension at 10 CFU/ml), calling into question the potential interest of including moxalactam in their recommendations.
View Article and Find Full Text PDFBackground: Devil's claw (Harpagophytum procumbens), turmeric (Curcuma longa), and bromelain are nutraceuticals that have demonstrated anti-inflammatory and analgesic properties and may be potential solutions in the treatment of acute or chronic joint pain. Their analgesic effect, however, is generally considered mild to moderate, and the relevance of their clinical use remains subject to discussion.
Objectives: The aim of the study was to evaluate the clinical relevance of the efficacy of a marketed complex of 3 plant extracts-H procumbens, C longa, and bromelain (AINAT, 650 mg)-in the treatment of degenerative joint pain.
Medical device SALs and surgical site infections: a mathematical model.
Biomed Instrum Technol
June 2012
It is commonly accepted that terminally sterilized healthcare products are rarely the source of a hospital-acquired infection (HAI). The vast majority of HAIs arise from human-borne contamination from the workforce, the clinical environment, less-than-aseptic handling techniques, and the patients themselves. Nonetheless, the requirement for a maximal sterility assurance level (SAL) of a terminally sterilized product has remained at 10(-6), which is the probability of one in one million that a single viable microorganism will be on a product after sterilization.
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