Publications by authors named "M B d'Arcy"
Article Synopsis
- Immunosuppressed individuals, such as those with HIV and solid organ transplant recipients, face a higher risk of developing certain cancers, prompting a study to identify specific cancer types associated with these conditions.* -
- Researchers analyzed cancer registry data in the U.S., finding a total of 38,047 cancer cases among organ transplant recipients and 53,592 among individuals with HIV, with elevated standardized incidence ratios of 1.66 and 1.49 respectively.* -
- Specific cancers, like conjunctival squamous cell carcinoma, showed significantly higher risks in both populations, while others, such as sebaceous adenocarcinoma, were particularly heightened in solid organ transplant recipients, emphasizing the need for awareness and monitoring in these
Mitophagy, a specialised form of autophagy, selectively targeting damaged or dysfunctional mitochondria, and is crucial for maintaining cellular homeostasis and mitochondrial quality control. Dysregulation of mitophagy contributes to various pathological conditions, including cancer, neurodegenerative and cardiovascular diseases. This review presents a comprehensive analysis of the molecular mechanisms, regulatory pathways, and interplay with other cellular processes governing mitophagy, emphasizing its importance in physiological and pathological contexts.
View Article and Find Full Text PDFThe Common Fund Data Ecosystem (CFDE) has created a flexible system of data federation that enables researchers to discover datasets from across the US National Institutes of Health Common Fund without requiring that data owners move, reformat, or rehost those data. This system is centered on a catalog that integrates detailed descriptions of biomedical datasets from individual Common Fund Programs' Data Coordination Centers (DCCs) into a uniform metadata model that can then be indexed and searched from a centralized portal. This Crosscut Metadata Model (C2M2) supports the wide variety of data types and metadata terms used by individual DCCs and can readily describe nearly all forms of biomedical research data.
View Article and Find Full Text PDFPurpose: Implausibly high algorithm-identified cancer incidence within a new user study after medication initiation may result from increased healthcare utilization (HU) around initiation ("catch-up care") that increases diagnostic opportunity. Understanding the relationships between HU prior to and around initiation and subsequent cancer rates and timing is important to avoiding protopathic bias.
Methods: We identified a cohort of 417 458 Medicare beneficiaries (2007-2014) aged ≥66 initiating an antihypertensive (AHT) after ≥180 days of non-use.