Moderate hypothermia improves neurobehavioral deficits after an epidural focal mass lesion in rodents.

The objective of this study was to evaluate the effects of a moderate, intraischemic hypothermia on the behavorial deficits up to 4 weeks after induction of a focal mass lesion. A focal epidural mass lesion was induced by an epidural balloon. The severity of the trauma was defined by the balloon volume and flattening of electroencephalography.

Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria.

Background: The authors previously reported that secondary carnitine deficiency may sensitize the heart to bupivacaine-induced arrhythmias. In this study, the authors tested whether bupivacaine inhibits carnitine metabolism in cardiac mitochondria.

Methods: Rat cardiac interfibrillar mitochondria were prepared using a differential centrifugation technique.