A new model of experimental diabetic cardiomyopathy using combination of multiple doses of anomer-equilibrated streptozotocin and high fat diet: sex matters.

Diabetes mellitus (DM) leads to a more rapid development of DM cardiomyopathy (dbCM) and progression to heart failure in women than men. Combination of high-fat diet (HFD) and freshly-injected streptozotocin (STZ) has been widely used for DM induction, however emerging data shows that anomer-equilibrated STZ produces an early onset and robust DM model. We designed a novel protocol utilising a combination of multiple doses of anomer-equilibrated STZ injections and HFD to develop a stable murine DM model featuring dbCM analogous to humans.

Endothelial Autophagy-related gene 7 Contributes to High Fat Diet-Induced Obesity.

Objective: Obesity-associated metabolic dysfunction is a major public health concern worldwide. Endothelial dysfunction is a hallmark of metabolic dysfunction, and endothelial cells affect metabolic functions. Because autophagy-related gene 7 (ATG7) is involved in various cellular physiology, we investigated the roles of endothelial cell-ATG7 (EC-ATG7) on high-fat diet-induced obesity and its related metabolic dysfunction.

Using predictive models to identify kelp refuges in marine protected areas for management prioritization.

Kelp forests serve as the foundation for shallow marine ecosystems in many temperate areas of the world but are under threat from various stressors, including climate change. To better manage these ecosystems now and into the future, understanding the impacts of climate change and identifying potential refuges will help to prioritize management actions. In this study, we use a long-term dataset of observations of kelp percentage cover for two dominant canopy-forming species off the coast of Victoria, Australia: Ecklonia radiata and Phyllospora comosa.