Rationalizing Photophysics of Co(III) Complexes with Pendant Pyrene Moieties.

Pendant organic chromophores have been used to improve the photocatalytic performance of many metal-based photosensitizers, particularly in first-row metals, by increasing π conjugation in ligands and lowering the energy of the photoactive absorption band. Using a combination of spectroscopic studies and computational modeling, we rationalize the excited state dynamics of a Co(III) complex containing pendant pyrene moieties, , where = 1,1'-(4-(pyren-1-yl)pyridine-2,6-diyl)bis(3-methyl-1-imidazol-3-ium). displays higher visible absorptivity, and blue luminescence from pyrene singlet excited states compared with [ = 1,1'-(pyridine-2,6-diyl)bis(3-methyl-1-imidazol-3-ium)] in which the pyrene moiety is absent.

Public Health.

Background: Both limited health literacy (HL) and elevated blood pressure variability (BPV) in later life have been associated with the risk of dementia and cognitive impairment. However, little is known about the relationship between HL, BPV, and domain-specific cognitive decline. We aimed to examine this relationship among primary care older adults.

Public Health.

Background: Poor sleep health has been associated with worse cognitive and health outcomes in older adults. Less is known about this relationship in midlife. Thus, we aimed to investigate the relationship between self-reported sleep health, cognitive function, and performance on common health tasks among middle-aged adults, as sleep may be a modifiable target to address later life risk of cognitive decline.

Public Health.

Background: Social determinants of health have been associated with disparities in health outcomes, including cognitive impairment and Alzheimer's disease. While individual-level disparities have been characterized, more research is needed into structural social determinants of health (SSDoH) and their association with cognitive outcomes, especially for those in midlife. This study aimed to investigate the association between SSDoH and subjective and objective measures of cognitive impairment.

Public Health.

Background: Impaired functional status is a central diagnostic feature of Alzheimer's disease and related dementias (ADRD). Informant reporting is often relied upon, given concerns surrounding the ability of persons with ADRD to validly self-report symptoms. We sought to investigate how cognitive impairment severity impacts psychometric properties of the Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS-PF) scale.