Publications by authors named "M B Whyte"
Background: Inhibitors of the renin-angiotensin-aldosterone system (RAAS), such as ACE inhibitors (ACEi), angiotensin-II receptor blockers and mineralocorticoid receptor antagonists, reduce morbidity and mortality in hypertension, congestive heart failure and chronic kidney disease. However, their use can lead to hyperkalaemia. We examined the proportions of RAAS inhibitor (RAASi) reduction or withdrawal, across GFR strata, following hospitalisation and the effect on patient mortality.
View Article and Find Full Text PDFAdoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with "off-the-shelf" allogeneic T cells directed to a combination of Epstein-Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration's Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder.
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- Cystic fibrosis (CF) is characterized by heightened neutrophil presence in the airways and inefficient apoptosis, prompting the investigation of whether NETosis (a form of neutrophil clearance) plays a significant role in CF lung disease.
- In a study involving 45 CF and 15 healthy participants, researchers found higher neutrophil counts and abnormal morphology in CF sputum, alongside elevated levels of inflammatory mediators and NETs, indicating a strong link between NETs and airway inflammation.
- Treatment with DNase reduced sputum NET levels and mitigated the pro-inflammatory effects of NETs in co-culture experiments, highlighting its potential as an anti-inflammatory therapy in CF management.
Article Synopsis
- A study analyzed data from the 2015 Nigeria Malaria Indicator Survey to map malaria prevalence across Nigeria's senatorial districts, identifying key factors influencing higher rates of infection in children under five.
- The highest malaria prevalence was found in Kebbi South district (70.6%), with significant associations linked to lower wealth, mothers’ secondary education, and lack of mosquito bed nets.
- Findings emphasized the spatial clustering of malaria and the importance of targeted intervention strategies to effectively reduce transmission in high-prevalence areas.