Publications by authors named "M B Vallerga"

Recent far-right and religious fundamentalist coalitions in Europe and the U.S. seek populist support through "anti-gender" rhetoric.

View Article and Find Full Text PDF

This mixed-methods study examined variables associated with use of experience-based (i.e., anecdotal) decisional strategies among 85 undergraduate students presented with 2 hypothetical lung cancer scenarios.

View Article and Find Full Text PDF

Fanconi Anemia (FA) is a rare autosomal recessive disorder characterized by hypersensitivity to inter-strand crosslinks (ICLs). FANCD2, a central factor of the FA pathway, is essential for the repair of double strand breaks (DSBs) generated during fork collapse at ICLs. While lesions different from ICLs can also trigger fork collapse, the contribution of FANCD2 to the resolution of replication-coupled DSBs generated independently from ICLs is unknown.

View Article and Find Full Text PDF
Article Synopsis
  • After UV irradiation, DNA polymerases, especially translesion DNA synthesis (TLS) polymerases like polη, help with DNA replication, but it's unclear if other factors are involved.
  • The study found that Rad51 recombinase plays a significant role in aiding DNA replication across UV lesions; its absence leads to slower S-phase progression and more cell death post-UV exposure.
  • Rad51 not only protects DNA synthesized before irradiation from degradation but also regulates the elongation process after exposure, highlighting the complexity of DNA repair mechanisms beyond just TLS pathways.
View Article and Find Full Text PDF