Publications by authors named "M B Spyres"
Background: Some North American rattlesnake venoms and angiotensin converting enzyme inhibitor (ACEI) medications each increase bradykinin levels in humans, with clinical effects attributable to bradykinin described in exposed populations. Influence of ACEI exposure on persons with snake envenomation has not been studied. We used data from the ACMT North American Snakebite Registry (NASBR) to determine if use of ACEI medications at the time of rattlesnake envenomation is associated with increased rate of systemic toxicity.
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- The American College of Medical Toxicology's Toxicology Investigators Consortium has been maintaining a national case registry since 2010, documenting patient consultations in hospitals and clinics regarding medical toxicology.
- In 2023, the registry recorded data from 7,392 patients, bringing the total number of cases since its inception to 102,331 across 36 sites with 61 healthcare facilities.
- Ethanol emerged as the most common exposure agent in 2023, followed by opioids and non-opioid analgesics, with a reported 98 fatalities (1.3% case fatality rate) and analyses of demographics and trends in toxicology consultations.
Availability of counterfeit prescription pills (counterfeit pills) containing illegally made fentanyl, including counterfeit M-30 oxycodone (counterfeit M-30) pills, has risen sharply in the United States and has been increasingly linked to overdose deaths. In 2023, approximately 115 million counterfeit pills were seized in U.S.
View Article and Find Full Text PDFBackground: Gender diversity in both emergency medicine and medical toxicology has grown over the last decade. However, disparities in promotion, awards, and speakership still exist. No studies have examined gender disparities in authorship in medical toxicology journals.
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- Intravenous lipid emulsion has been proposed as a potential antidote for toxic drug overdoses based on the "lipid sink" theory, which suggests it can help sequester lipophilic drugs in the bloodstream.
- The study analyzed 134 cases from a toxicology registry to see if the survival rate after lipid therapy was related to the lipophilicity of the intoxicants involved.
- Results showed that 80.6% of patients survived, but there was no significant link between the intoxicant's lipophilicity and survival; however, systolic blood pressure improved for both groups after treatment.