Background: Predictive biomarkers for immune checkpoint inhibitors (ICIs), e.g., programmed death ligand-1 (PD-L1) tumor proportional score (TPS), remain limited in clinical applications.
View Article and Find Full Text PDFWe derive a scheme by which to solve the Liouville equation perturbatively in the nonlinearity, which we apply to weakly nonlinear classical field theories. Our solution is a variant of the Prigogine diagrammatic method and is based on an analogy between the Liouville equation in infinite volume and scattering in quantum mechanics, described by the Lippmann-Schwinger equation. The motivation for our work is wave turbulence: A broad class of nonlinear classical field theories are believed to have a stationary turbulent state-a far-from-equilibrium state, even at weak coupling.
View Article and Find Full Text PDFBackground: Operative risk for supra-aortic trunk (SAT) surgical revascularization for occlusive disease, particularly transthoracic reconstruction (TR), remains ill-defined. This study sought to describe and compare 30-day outcomes of TR and extra-anatomic (ER) SAT surgical reconstruction for an occlusive indication across the United States over a contemporary 15-year period.
Methods: Using the National Surgical Quality Improvement Program, TR and ER performed during 2005-2019 were identified.