Management of asynchronous multifocal adult glioblastoma with loss of BRAF -mutant clonality: a case report.

Glioblastoma (GBM) classification involves a combination of histological and molecular signatures including IDH1/2 mutation, TERT promoter mutation, and EGFR amplification. Non-canonical mutations such as BRAF, found in 1-2% of GBMs, activate the MEK-ERK signaling pathway. This mutation can be targeted by small molecule inhibitors, offering therapeutic potential for GBM.

A 25 Year Update on the Facial Nerve Sparing Approach for Vestibular Schwannoma.

Background And Objectives: This article aims to report results of our facial nerve preservation approach to treating vestibular schwannomas (VS) at a single institution by a single surgeon performing both microsurgery (MS) and stereotactic radiosurgery (SRS).

Methods: We retrospectively reviewed 751 patients at our institution between 1998 and 2023 by intervention received: retrosigmoid microsurgery (MS, Group 1, 217 patients), gamma knife stereotactic radiosurgery (SRS, Group 2, 462 patients), MS then SRS (Group 3, 72 patients), SRS then MS (Group 4, 10 patients), and SRS then SRS (Group 5, 5 patients). No patients had MS followed by MS.

Search for Fractionally Charged Particles with CUORE.

The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5  cm×5  cm×5  cm TeO_{2} crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in ^{130}Te. Unprecedented in size among cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic throughgoing particles. Using the first tonne year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various standard model extensions and would have suppressed interactions with matter.

Simultaneous Measurement of the Half-Life and Spectral Shape of ^{115}In β Decay with an Indium Iodide Cryogenic Calorimeter.

Current bounds on the neutrino Majorana mass are affected by significant uncertainties in the nuclear calculations for neutrinoless double-beta decay. A key issue for a data-driven improvement of the nuclear theory is the actual value of the axial coupling constant g_{A}, which can be investigated through forbidden β decays. We present the first measurement of the 4th-forbidden β decay of ^{115}In with a cryogenic calorimeter based on indium iodide.

Synthetic CT for gamma knife radiosurgery dose calculation: A feasibility study.

Purpose: To determine if MRI-based synthetic CTs (sCT), generated with no predefined pulse sequence, can be used for inhomogeneity correction in routine gamma knife radiosurgery (GKRS) treatment planning dose calculation.

Methods: Two sets of sCTs were generated from T1post and T2 images using cycleGAN. Twenty-eight patients (18 training, 10 validation) were retrospectively selected.