Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review.

Objective: To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting.

Methods: Retrospective chart review by psychiatrists on staff at a university hospital identified all patients who had received pramipexole. Response was based on moderate to marked improvement in the Clinical Global Impression-Improvement (CGI-I) scale.

[Morphological characteristics of central and peripheral organs of rat immune system in time course of adaptation to external low-dose gamma irradiation].

The morphohistochemical changes in immune system lymphoid organs and skin of rats, exposed to single and fractionated gamma-radiation (0.35 Gy) were studied during 1 month. It has been revealed that single irradiation didn't significantly influence, while the fractionated irradiation in equal dose resulted in lymphoid cells elimination from thymus and spleen and changes in skin and bone marrow cells subsets, inducing the increase of lymphoid cells number and activation of tissue basophils and macrophages reaction.

[The role of the thymus gland in the development of adaptation reactions of the immune system during fractionated low-level gamma irradiation].

In experiments with normal and thymectomized rats it has been revealed that exposure of normal animals to 0.35 Gy of gamma-radiation induces changes in blood cells subsets, depression of NK functional activity, decrease in polymorphonuclear leukocyte basal chemiluminescence level, suppression of the delayed type of hypersensitivity reaction and stimulation of local IgE-synthesis in respiratory organs. At the same time irradiation of adult thymectomized animals did not resulted in significant fluctuations in cellular and humoral immunity indices as well as blood cells functional activity level.

[The functional dynamics of the system of immunity in rats during adaptation to single and fractionated exposures to low doses of external gamma irradiation].

The content of serum corticosterone so as immunological and nonspecific reactivity in rats exposed to single or fractionated gamma-radiation (0.35 Gy) were studied during 1 month. It has been revealed that corticosterone level, dynamics of absolute amount of leucocytes, lymphocytes, Rc-receptor-bearing cells in blood, relative content of FcR(+)-cells in bone marrow, spleen and peripheral lymph nodes of irradiated animals depend on the scheme of irradiation.