Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery.

When exposed to the biological environment, nanoparticles (NPs) form a protein corona that influences delivery profile. We present a study of protein corona formation and NP biodistribution in amniotic fluid (AF) for poly(lactic-co-glycolic acid) (PLGA) and poly(lactic-acid) (PLA) NPs, with and without polyethylene glycol (PEG), as well as poly(amine-co-ester)-PEG (PACE-PEG) NPs. The presence of surface PEG and polyvinyl alcohol (PVA) were characterized to investigate surfactant role in determining protein corona formation.

The Association Between Sex and Lung Cancer Screening Adherence to Follow-Up in a Cohort of Veterans.

The 2021 update to the United States Preventive Services Task Force guidelines for lung cancer screening (LCS) aims to reduce disparities derived from sex, race/ethnicity, and socioeconomic status. Few studies have addressed adherence to LCS among female Veterans. To evaluate differences in adherence to LCS by sex, we conducted a retrospective cohort study within the VA Connecticut LCS Program between June 2013 and March 2020.

[Clinical research in oncology in French Overseas Territories: Challenges, strengths, and available resources].

Introduction: Reducing territorial inequalities in access to care and innovations in oncology is an objective of the ten-year strategy to fight cancer. The populations of Overseas Territories (OT) face limits in terms of access to clinical research in oncology (CRO).

Methods: The article aims to share an exhaustive inventory of the challenges observed in the development of CRO in the OT but also the means identified to respond to them, illustrated with recent successes in terms of setting up a CRO program.

Multi-dimensional outcomes following extracorporeal cardiopulmonary resuscitation.

Background: Recent trials suggested that extracorporeal cardio-pulmonary resuscitation (ECPR) with veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or "ECMELLA" (VA-ECMO plus Impella®) may improve short-term survival and neurological outcomes in selected patients with refractory cardiac arrest. However, long-term effects on cardiac, cognitive, physical and psychological health need further study. A multidisciplinary post-ECPR outpatient care program was developed at two centers, involving cardiologists, neurologists, psychologists and medical sociologists to assess seven key health dimensions.