Challenges to innovation arising from current companion diagnostics regulations and suggestions for improvements.

A companion diagnostic is a diagnostic test that provides information essential for the safe and effective use of a corresponding therapeutic product. To obtain marketing approval, the companion diagnostic must demonstrate acceptable analytical and clinical performance. Companion diagnostic regulations are intended to protect patients by ensuring quality and consistency of treatment-guiding biomarker testing in clinical trials and clinical practice.

The nature of grief: implications for the neurobiology of emotion.

This paper explores the limitations of neurobiological approaches to human emotional experience, focusing on the case of grief. We propose that grief is neither an episodic emotion nor a longer-term mood but instead a heterogeneous, temporally extended process. A grief process can incorporate all manner of experiences, thoughts, and activities, most or all of which are not grief-specific.

Participation in Non-small Cell Lung Cancer Clinical Trials in the United States by Race/Ethnicity.

Introduction: Despite efforts by Cancer Centers and community organizations to increase diversity in clinical trials, significant racial/ethnic disparities remain. Given the high mortality rates in non-small cell lung cancer (NSCLC), it is important to increase diversity in NSCLC trials, ensuring all patients benefit from advances in new treatment modalities.

Materials And Methods: We evaluated the distribution of racial/ethnic minority enrollment in NSCLC clinical trials using data from ClinicalTrials.

Imaging of Odontogenic Sinusitis.

Odontogenic sinusitis (ODS) has been shown to be the most common cause of unilateral maxillary sinus opacification on computed tomography scans. Review of the maxillary alveolar ridge and maxillary tooth roots, and their relationships to the maxillary sinus floor is essential when interpreting paranasal sinus imaging. In recent years, ODS has received increased attention in the recent otolaryngologic and dental literature.