Sodium thiosulfate treatment rescues hyperglycaemia-induced pronephros damage in zebrafish by upregulating nitric oxide signalling.

Sodium thiosulfate (STS) is gaining increasing attention in research for its potential therapeutic applications across a spectrum of disease processes beyond its current uses. However, the precise mechanisms of action remain incompletely understood. We investigated the efficacy of STS in treating hyperglycaemia-induced pronephros damage in zebrafish to gain further insight into the underlying mechanisms.

[Program "reproductive health of boys" in Samara region].

Because of great importance of early detection of urological pathology in boys, we made a prophylactic examination of boys aged 2-17 years. Pediatric urologists-andrologists examined 20402 boys for 2008-2009. They detected: diseases of the penis (11.

[Epidemiology of bladder cancer in the Samara region].

Correlation and regression analyses were used to study effects of exogenic and endogenic epidemiological factors. The findings of the two methods were almost identical. Of epidemiological factors in males under 50 years of age most essential were smoking and drinking regime.

[A complex approach to prediction of long-term results of urinary bladder cancer treatment].

Our investigations proved that the risk of bladder cancer relapse increases after organ-preserving treatment in exposure to exogenic and endogenic epidemiological factors. A significant deterioration of the prognosis as concerns a recurrence and lethal outcome risk is significantly related with some clinical and morphological characteristics of the tumor. The correlation-regression analysis has revealed a complex of the most significant independent factors which made a basis for a developed mathematic model of bladder cancer prognosis and a computer program for bladder cancer patients survival.