The 3Rs principles-reduction, refinement, replacement-are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals. Minimizing their distress, reducing their number as well as searching for means to replace them in experimental studies are constant objectives in this area. Due to its non-invasive character imaging supports these efforts by enabling repeated longitudinal assessments in each animal which serves as its own control, thereby enabling to reduce considerably the animal utilization in the experiments.
View Article and Find Full Text PDFAccording to the defined challenge of cross-border delivery, a pilot experiment based on the integration of new digital technologies to assess process optimization potential in the postal sector was designed. The specifics were investigated with events processing based on digital representation. Different events were simulated with scenario analysis with the integration of the Cognitive Advisor and supported by the monitoring of KPIs.
View Article and Find Full Text PDFThe roof plate-specific spondin-leucine-rich repeat-containing G-protein coupled receptor 4/5 (LGR4/5)-zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation. However, its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. The current study investigated whether hepatic epithelial cell-specific loss of the Wnt/β-catenin modulator Lgr4/5 promoted NAFLD.
View Article and Find Full Text PDFObjective: To evaluate the accuracy of 4 equations validated for the general population to determine resting energy expenditure (REE) in polio survivors.
Design: A descriptive, ambispective, single-center observational cohort study of minimal risk care.
Setting: Tertiary university care hospital.
Int J Environ Res Public Health
September 2022
The importance of sustainability in supply chain management is growing worldwide. It is possible to find reasons for this using various phenomena that negatively affect humanity, e.g.
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