Effect of a combination of the new antischistosomal drug Ro 15-5458 and praziquantel on different strains of Schistosoma mansoni infected mice.

The possible additive or synergistic effects of both praziquantel (CAS 55268-74-1) and a new antischistosomal drug, Ro 15-5458 (10-(2-diethylamino)thyl)-9-acridanone(thiazolidin-2-yl-i dene)hydrazone, CAS 92928-47-7) were studied in two different strains of Schistosoma mansoni infected mice, namely CD susceptible and SO4 resistant strains. Assessment of cure was performed using the following parameters: hepatic and intestinal tissue egg load and distribution, oogram changes in the small intestine and histopathological examination of the mice livers. In this study, a combination was used between 1/3 the curative doses of praziquantel and Ro 15-5458.

Progesterone concentration in defatted milk of dairy cows in early pregnancy.

Progesterone concentrations have been measured in defatted milk of British Friesian cows of four herds during the oestrus cycles (other than short cycles) immediately before artificial insemination (AI) at oestrus and immediately after AI (in non-pregnant cows), and during early pregnancy. Differences in mean progesterone concentrations between herds were significant (P less than 0.05) on all days within the day 10-18 period after AI, both in pregnant and in non-pregnant, inseminated cows but were not significant between pregnant and non-pregnant cows within herds until day 17 or 18.

Effect of protein energy malnutrition (PEM) on spermatogenesis in rat testis.

In this work 60 male albino rats were subjected to a feeding experiment aimed to study the influence of protein free and reduced diets on normal function of rat testes. It was shown that the PEM exerts adverse effects on testicular function, the nature and severity of these effects depend on the duration of the deficiency state. Histological examination of rat testis, revealed that the spermatogenesis is arrested at spermatogonium stage in rats fed on protein free diet, and at primary and secondary spermatocyte stage in rats fed on normal but reduced diet.

Biochemical and haematological aspects of anaemia associating protein energy malnutrition (PEM).

Haematological as well as biochemical parameters assessing anaemia associating protein energy malnutrition PEM were estimated. Data revealed that controls studied have a relatively lower Hb, Ht, and R.B.