Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlled trial.

Objective: To investigate the safety, feasibility and acceptability of the Neurofenix platform for upper-limb rehabilitation in acute and subacute stroke.

Design: A feasibility randomised controlled trial with a parallel process evaluation.

Setting: Acute Stroke Unit and participants' homes (London, UK).

Mapping hotspots of zoonotic pathogen emergence: an integrated model-based and participatory-based approach.

Background: An increase in pandemics of zoonotic origin has led to a growing interest in using statistical prediction to identify hotspots of zoonotic emergence. However, the rare nature of pathogen emergence requires modellers to impose simplifying assumptions, which limit the model's validity. We present a novel approach to hotspot mapping that aims to improve validity by combining model-based insights with expert knowledge.

Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer.

Introduction: The impact of endoplasmic reticulum (ER) stress in tumor-associated cells, such as cancer associated fibroblasts (CAFs), immune cells and endothelial cells, on patient outcomes in clinical specimens have not been examined. For the first time, we characterized the expression and spatial locations of ER stress markers, BiP and CHOP, in tumor-associated cells and assessed their prognostic significance in a panel of pancreatic ductal adenocarcinoma (PDAC) patient samples.

Methods: Multiplex immunofluorescence was performed on tumor microarrays and images were analyzed using HALO AI software.

Toxin and capsule production by Bacillus cereus biovar anthracis influence pathogenicity in macrophages and animal models.

Bacillus cereus biovar anthracis (Bcbva) causes anthrax-like disease in animals, particularly in the non-human primates and great apes of West and Central Africa. Genomic analyses revealed Bcbva as a member of the B. cereus species that carries two plasmids, pBCXO1 and pBCXO2, which have high sequence homology to the B.

Stressful Body Temperatures as a Maternal Effect on Lizard Reproduction.

AbstractUnderstanding the relationship between the environment parents experience during reproduction and the environment embryos experience in the nest is essential for determining the intergenerational responses of populations to novel environmental conditions. Thermal stress has become commonplace for organisms inhabiting areas affected by rising temperatures. Exposure to body temperatures that approach, but do not exceed, upper thermal limits often induces adverse effects in organisms, but the propensity for these temperatures to have intergenerational consequences has not been explored in depth.