[Pharmacotherapeutic pathomorphosis of schizophrenia].

A comparative study of over 4000 case histories of patients admitted to the Kashchenko Moscow psychiatric hospital in 1951 and 1974 demonstrated that the character of natural history of schizophrenia under conditions of polypharmacotherapy has changed. The drug pathomorphosis was studied by comparing the clinical picture of the psychosis in the preneuroleptic period and under conditions of polypharmacotherapy. In polypharmacotherapy the ratio of the form of schizophrenia has changed towards an increase of attack-like forms and a drop in the number of cases with continuous forms of the disease.

[Long-term treatment of schizophrenic patients with leponex (clozapine)].

The authors studied a prolonged (3--5 years) use of leponex in 23 patients with the most progressive forms of schizophrenia (hebephrenic, paranoid and close to them attack-like). The study included the influence on the frequency and duration of relapses, on the dynamics of the so-called productive and negative disorders and social adaptation. The achieved data indicate that leponex possesses certain advantages compared to other neuroleptical drugs in prolonged maintenance therapy.