A sex-dependent algorithm including kappa free light chain for multiple sclerosis diagnosis.

Multiple sclerosis (MS) diagnosis includes the presence of restricted oligoclonal bands (OCB) in cerebrospinal fluid (CSF), but it has several limitations, as it is an observer-dependent time-consuming technique and offers a dichotomous result. Thus kappa free light chains (KFLC) have emerged as a quantitative alternative. However, the cut-off values for KFLC have not been well established yet and it is not clear if differences between sexes exist.

Biochemical biomarkers for multiple sclerosis.

Introduction: Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system. Although there is currently no definite cure for MS, new therapies have recently been developed based on a continuous search for new biomarkers.

Development: MS diagnosis relies on the integration of clinical, imaging and laboratory findings as there is still no singlepathognomonicclinical feature or diagnostic laboratory biomarker.

Tungiasis in a southern tamandua (Tamandua tetradactyla) from Formosa province, Argentina.

Tunga penetrans causes tungiasis, a parasitic disease of humans and domestic animals. In this work we report the presence of tungiasis in the southern tamandua (Tamandua tetradactyla) from Formosa, Argentina. An individual of southern tamandua was found dead on the roadside and it presented lesions consisted with neosomes located on its four limbs.

Coordination Chemistry of Cu Complexes of Small N-Alkylated Tetra-azacyclophanes with SOD Activity.

A new tetraaza-pyridinophane macrocycle (L1) N-alkylated with two isopropyl and one methyl groups symmetrically disposed has been prepared and its behavior compared with those of the unsubstituted pyridinophane (L3) and the related compound with three methyl groups (L2). The protonation studies show that, first, a proton binds to the central methylated amine group of L1, while, second protonation leads to a reorganization of the protons that are at this stage attached to the lateral isopropylated amines. The X-ray structure of [HL1] agrees with the UV-vis and NMR studies as well as with the results of DFT calculations.

A Potential New Threat to Wild Life: Presence of UV Filters in Bird Eggs from a Preserved Area.

The present study uses bird eggs of seven wild species as a biomonitoring tool for sunscreens occurrence. Seven UV filters (UV-Fs), including 3 hydroxy-metabolites of oxybenzone (benzophenone 3, BP3) were characterized in unhatched eggs from Doñana Natural Space (Spain). High frequency of detection was observed for all UV-Fs, ranging from 95% to 100%.