Publications by authors named "M B Madsen"
Aim: To investigate liver biochemistry in infants screened for biliary atresia (BA) at the time of hepatobiliary scintigraphy (HS) and to evaluate the effect of change in threshold for HS.
Methods: Infants born from 2010 to 2021, who underwent HS <6 months postpartum for BA, were included and data sourced from electronic medical records. The change in threshold in 2018 from ≥20 (and/or if conjugated bilirubin exceeds 20% of total bilirubin) to ≥17 μM (regardless of total bilirubin) was evaluated.
Article Synopsis
- Spontaneous preterm birth (SPTB) is a major cause of health issues in newborns and can arise from various unknown genetic factors, prompting the need for better understanding through family studies.
- The research utilized the Utah Population Database to identify large families with multiple cases of early SPTB and focused on seven specific pedigrees for genetic analysis, excluding other known causes of preterm birth.
- The study discovered two significant chromosomal regions related to SPTB, particularly in chromosome 8 (8q24.23), suggesting potential genetic markers for this condition.
Background: Using [F]altanserin, a serotonin 2A receptor (5-HTR) antagonist Positron Emission Tomography (PET) tracer, a positive association between cortical 5-HTR binding and the inward-directed facets of neuroticism has been demonstrated in healthy individuals. Psilocybin, a 5-HTR agonist, shows promise for the treatment of depression, reducing neuroticism and mood symptoms potentially via hypothalamic-pituitary-adrenal (HPA) modulation. 5-HTR and neuroticism are both modulated by HPA axis function.
View Article and Find Full Text PDFTreatment regimens and glycaemic outcomes in more than 100 000 children with type 1 diabetes (2013-22): a longitudinal analysis of data from paediatric diabetes registries.
Lancet Diabetes Endocrinol
January 2025
Background: Advances in paediatric type 1 diabetes management and increased use of diabetes technology have led to improvements in glycaemia, reduced risk of severe hypoglycaemia, and improved quality of life. Since 1993, progressively lower HbA targets have been set. The aim of this study was to perform a longitudinal analysis of HbA, treatment regimens, and acute complications between 2013 and 2022 using data from eight national and one international paediatric diabetes registries.
View Article and Find Full Text PDFArticle Synopsis
- A study examined the prevalence and risk factors of acne in transgender men undergoing gender-affirming masculinizing testosterone therapy (GATT) from 2010 to 2019, involving 323 participants.
- The findings revealed that the prevalence of moderate to severe acne increased significantly from 11.8% to 39.1% within the first year of GATT.
- Key risk factors for developing moderate/severe acne included having a body mass index (BMI) over 25, being younger (ages 18-25), higher testosterone levels, and pre-existing acne, suggesting important considerations for healthcare providers when counseling patients.