Publications by authors named "M B Lanteri"
Article Synopsis
- - COVID-19 convalescent plasma (CCP) may be beneficial for immunocompromised patients, but the FDA's current threshold for qualifying plasma based on antibody levels might be too low.
- - A study evaluated antibody levels in blood donors with different infection and vaccination histories, revealing that those with hybrid immunity (infection followed by vaccination) had higher antibody levels and better neutralizing capabilities.
- - The research suggests establishing new test-based criteria for qualifying CCP, highlighting that plasma with high antibody levels could effectively neutralize various COVID-19 variants for several months after infection or vaccination.
Background: Combining pathogen reduction technology (PRT) with blood screening may alleviate concerns over the risk of transfusion-transmitted infections (TTI) and support changes in blood donor selection to potentially increase blood availability. This study aimed to estimate the residual risk of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) transfusion-transmission in Canada after implementing PRT, while eliminating deferrals for sexual risk behaviors.
Study Design And Methods: A probabilistic approach that combined Bayesian networks with Monte Carlo simulations was used to estimate the risk of transfusing HIV-, HBV-, or HCV-contaminated blood components.
Article Synopsis
- Long COVID is a complex condition affecting about 12% of COVID-19 survivors, with various symptoms and no widely accepted definition, pushing researchers to study its immune profile.
- A survey of over 33,000 blood donors revealed that higher levels of anti-nucleocapsid antibodies are linked to an increased risk of long COVID, while higher anti-spike IgG levels can reduce that risk.
- The study identified four clinical subphenotypes—ranging from neurological to multi-systemic symptoms—suggesting that different immune responses may contribute to varied long COVID experiences.
Article Synopsis
- * A study involving 142,599 blood donors established a new, lower threshold for detecting past infections using the Ortho VITROS Anti-SARS-CoV-2 Total-N Antibody assay, which boosted detection sensitivity while keeping specificity above 98%.
- * The updated test showed a high sensitivity of 98.1% for unvaccinated individuals and 95.6% for those who were vaccinated, though sensitivity was influenced by factors like the virus variant, donor age,
Introduction: Cardiometabolic diseases are associated with greater COVID-19 severity; however, the influences of cardiometabolic health on SARS-CoV-2 infections after vaccination remain unclear. Our objective was to investigate the associations between temporal blood pressure and total cholesterol patterns and incident SARS-CoV-2 infections among those with serologic evidence of vaccination.
Methods: In this prospective cohort of blood donors, blood samples were collected in 2020-2021 and assayed for binding antibodies of SARS-CoV-2 nucleocapsid protein antibody seropositivity.