Associations between (pharmaco-)genetic markers and postoperative pain after inguinal hernia repair - a prospective study protocol.

Background: Postoperative pain is a common complication following surgery, with severity and duration varying between patients. Chronic postoperative pain after inguinal hernia surgery has an incidence rate of approximately 10%. Risk factors for acute and chronic pain following hernia surgery include age, sex, psychosocial factors, and demographic background.

Applicability of alkali beam emission spectroscopy on NSTX-U.

Understanding fast pedestal dynamics and turbulent transport in the edge and scrape-off layer (SOL) plasma of spherical tokamaks is crucial for the design and operation of future fusion reactors. The alkali beam emission spectroscopy diagnostic technique offers a means to measure the absolute electron density radial profile and fluctuation amplitude in these regions. In this study, we demonstrate that injecting a sodium neutral beam radially into the plasma and analyzing the light emission from its 3p-3s atomic transition using near-orthogonal viewing angles allows for accurate measurement of the electron density profile and fluctuations in the National Spherical Torus Experiment (NSTX) Upgrade spherical tokamak.

Overcoming Barriers: Strategies for Implementing Pharmacist-Led Pharmacogenetic Services in Swiss Clinical Practice.

There is growing evidence that pharmacogenetic analysis can improve drug therapy for individual patients. In Switzerland, pharmacists are legally authorized to initiate pharmacogenetic tests. However, pharmacogenetic tests are rarely conducted in Swiss pharmacies.

Recurrent high creatine kinase levels under clozapine treatment - a case report assessing a suspected adverse drug reaction.

Suspected adverse drug reactions (ADRs) during treatment with clozapine often prompt therapeutic drug monitoring (TDM) in clinical practice. Currently, there is no official recommendation for pharmacogenetic (PGx) testing in the context of clozapine therapy. In this case report, we demonstrate and discuss the challenges of interpreting PGx and TDM results highlighting the possibilities and limitations of both analytical methods.