Publications by authors named "M B Knudson"
Background And Objectives: The AAP's Clinical Practice Guidelines (CPG) for febrile infants provides recommendations in evaluating well-appearing febrile infants aged 8-60 days at risk for invasive bacterial infections (IBIs; ie, bacteremia and bacterial meningitis). However, guidance remains limited for the infants excluded from (ie, ineligible for) the CPG. The objectives are to estimate the proportion of well-appearing CPG-ineligible febrile infants and to examine CPG performance in detecting IBIs for CPG-ineligible febrile infants.
View Article and Find Full Text PDFIntroduction: Pelvic fractures are associated with a high risk of venous thromboembolism (VTE). Among treatment options, including pelvic angioembolization (PA), preperitoneal pelvic packing (PPP), and pelvic open reduction internal fixation (ORIF), PPP has been postulated as a VTE risk factor. We aimed to characterize the risk of VTE among pelvic fracture patients receiving PPP, PA or ORIF.
View Article and Find Full Text PDFWeight-based enoxaparin thromboprophylaxis in young trauma patients: analysis of the CLOTT-1 registry.
Trauma Surg Acute Care Open
February 2024
Introduction: Optimal venous thromboembolism (VTE) enoxaparin prophylaxis dosing remains elusive. Weight-based (WB) dosing safely increases anti-factor Xa levels without the need for routine monitoring but it is unclear if it leads to lower VTE risk. We hypothesized that WB dosing would decrease VTE risk compared with standard fixed dosing (SFD).
View Article and Find Full Text PDFAchievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.
Phys Rev Lett
February 2024
Article Synopsis
- * This experiment produced 2.05 MJ of laser energy, resulting in 3.1 MJ of total fusion yield, which exceeds the Lawson criterion for ignition, demonstrating a key milestone in fusion research.
- * The report details the advancements in target design, laser technology, and experimental methods that contributed to this historic achievement, validating over five decades of research in laboratory fusion.
Article Synopsis
- Pneumonia can lead to higher complications and costs in ICUs, making early detection crucial, but effective early biomarkers are currently lacking.
- A study evaluated fibrinolysis resistance (FR) using thrombelastography in patients after major abdominal surgery to see if it correlates with pneumonia risk; results showed that a specific cutoff of less than 4% at 24 and 48 hours significantly increased pneumonia rates.
- In diverse patient cohorts, including those with traumatic brain injury, the tPA-TEG measurement was identified as a strong risk factor for pneumonia, highlighting the need for further research to validate these findings and improve early identification methods.