Reflections of Foster Youth Engaging in the Co-Design of Digital Mental Health Technology: Duoethnography Study.

Background: Current research on digital applications to support the mental health and well-being of foster youth is limited to theoretical applications for transition-aged foster youth and support platforms developed without intentional input from foster youth themselves. Centering the lived expertise of foster youth in digital solutions is crucial to dismantling barriers to care, leading to an increase in service access and improving mental health outcomes. Co-design centers the intended end users during the design process, creating a direct relationship between potential users and developers.

Coaxial Helices in Chiral Supramolecular Aggregates from Highly Hindered Chiral Allenes.

Chiral allenes self-assembly following a cooperative mechanism into a supramolecular chiral aggregate consisting of two coaxial helices: the internal helix described by the allene stack and the external helix which consist in a 4-helix described by the four allene substituents. More precisely, this supramolecular aggregate possesses six axially chiral elements within its structure-the allene, the allene stack (internal helix) and the stacks of the four allene substituents (external 4-helix)-. Interestingly, slight variations in the magnitude of the tilting degree while keeping its P- or M- orientation (internal helix) can vary the orientation of the 4-axial motifs at the external helix.

Targeting interleukin-6 pathways in giant cell arteritis management: A narrative review of evidence.

Giant cell arteritis (GCA) is a chronic inflammatory vasculitis with a significant impact on vascular and patient health. It may present with non-specific symptoms and can lead to severe complications if not managed effectively. This narrative review explores the treatment of GCA with interleukin-6 (IL-6) pathway inhibitors, focusing on key studies from selected databases published between 2018 and 2024.

The timing of marine heatwaves during the moulting cycle affects performance of decapod larvae.

Marine heatwaves (MHW) pose an increasing threat and have a critical impact on meroplanktonic organisms, because their larvae are highly sensitive to environmental stress and key for species' dispersion and population connectivity. This study assesses the effects of MHW on two key moulting cycle periods within first zoea of the valuable crab, Metacarcinus edwardsii. First, the changes in swimming behaviour during zoea I were recorded and associated to moult cycle substages.