Most severe neutropenia in individuals with no chronic condition did not result in a specific diagnosis.

Background And Objectives: This study estimated the incidence of unexplained severe neutropenia (neutrophil count 500 x 10(6)/L) and hospitalized morbidity in the year after a finding of severe neutropenia in persons 2 years of age or older based on clinical laboratory data.

Methods: Computer-stored data from the Kaiser Permanente Laboratory Management System/Results Management System were used to identify findings of severe neutropenia in members of Kaiser Permanente Southern California 2 years of age or older during the period January 1, 1997, through December 31, 1999. Computer record linkage and medical record review were used to exclude individuals with chronic disease or treatments with bone marrow toxic drugs known to cause neutropenia.

Prophylaxis and therapy with factor VII concentrate (human) immuno, vapor heated in patients with congenital factor VII deficiency: a summary of case reports.

Hereditary factor VII deficiency is a rare autosomal recessive condition, usually associated with normal or reduced levels of a functionally defective molecule. The available means of treating this condition in North America presents serious health risks to the patient. Transfusion with fresh frozen plasma carries a risk of volume overload and a significant risk for viral transmission.

Agranulocytosis related to vancomycin therapy.

A patient with renal failure due to Goodpasture's syndrome was treated with vancomycin. After he had received 3 g of the drug, his white blood cell count fell to a level of 200/microliter. Bone marrow biopsy disclosed severe myeloid hypoplasia.