Guideline on managing thumb base osteoarthritis: The British Society for Surgery of the Hand Evidence for Surgical Treatment (BEST) findings and recommendations.

This review paper provides a summary of the evidence for non-surgical and surgical management of thumb base osteoarthritis and suggests guidelines through including and a . The guidelines were developed through systematic reviews in accordance with the British Society for Surgery of the Hand Evidence for Surgical Treatment (BEST) Process Manual, which has been accredited by the National Institute for Health and Care Excellence. A stepwise approach is recommended with initial non-invasive treatment consisting of a comprehensive and multimodal package of supported self-management.

Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles.

Macrocyclic peptides containing a thiazole heterocycle exhibit fascinating properties in natural products and future therapeutics. We report a biocompatible macrocyclisation approach facilitated by an N-terminal cysteine and C-terminal nitriles. The use of various chiral α-amino nitriles enables the incorporation of diverse hydrophobic side chains adjacent to the thiazole motif.

Guidance for delivering surgical procedures outside operating theatres: scoping review.

Background: This review aimed to examine in-depth the extent and content of guidance related to the delivery of surgical procedures outside of the operating theatre.

Methods: Documents concerning the delivery of surgical procedures in non-operating theatre settings were eligible for inclusion. Guidance documents were identified from three sources: electronic databases (MEDLINE and Embase), professional organization websites and expert knowledge.

Frustrated Lewis Pairs from Al-E Bonds (E=Ge, Sn, Pb).

The potassium aluminyl K[Al(NON)] ([NON]=[O(SiMeNDipp)], Dipp=2,6-iPrCH) reacts with group 14 chloroamidinates E(Am)Cl (E=Ge, Sn, Pb. [Am]=[tBuC(NDipp)]) to form (NON)Al-E(Am) Lewis pairs with unsupported Al-E bonds, including the first structurally authenticated Al-Pb bond. Analysis using spectroscopic (NMR, UV-vis and Mössbauer for E=Sn), X-ray diffraction and computational (DFT, QTAIM, TD-DFT) methods conclude an Al-E σ-bond derived from a Lewis basic Al and a Lewis acidic tetrylene, with back-donation from the E s-orbital lone pair donor NBO to acceptor NBOs on Al that are derived from s/p-orbitals.

New genomic resources inform transcriptomic responses to heavy metal toxins in the common Eastern bumble bee Bombus impatiens.

Background: The common Eastern bumble bee Bombus impatiens is native to North America and is the main commercially reared pollinator in the Americas. There has been extensive research on this species related to its social biology, applied pollination, and genetics. The genome of this species was previously sequenced using short-read technology, but recent technological advances provide an opportunity for substantial improvements.